Dechra Brand Guidelines

Derm Sales Aid

WHY IS IT TIME TO CHANGE?

Antimicrobial resistance

What needs to happen? Theprudent and appropriate useof antimicrobials where indicated, aswell asmeasures tominimise occurrence and recurrenceof infections.

Causes

• Antibiotics are essential for the treatmentof manybacterial infections • Resistantbacteria are emerging and spreading 1,2 • The spread is thought tobe acceleratedby the inappropriate useof therapeutic antimicrobials • Thepotential consequences are severe 3

Awide varietyof conditions can cause thisopportunisticovergrowth, includingbreedpredisposition, a compromised immune system and/or adisrupted skinbarrier. 5

WHEN WILL HIS SKIN INFECTION BECOME UNTREATABLE?

What is recommended?

Why?

• Abestpractice approach todiagnosis • Aholistic approach to control and maintenance • Prudent and appropriateprescribing of antimicrobials • Useof topicalproductswhere appropriate

• Reduces the riskof recurrenceof thedisease • Maintenance sustainspet health and enforcesowner compliance • Happier clients and healthierpets • Improved lifetime valueof your clients • Safeguard antibiotic efficacy for the future

1.Seborrhoeicdermatitis associatedwith Malassezia pachydermatis and Staphylococcus pseudintermedius

2.Primary atopy and concurrent Malasseziadermatitis

3.DogwithCushing’sdisease and secondary Malassezia dermatitis

Consequences Malasseziadermatitis indogsmaybe localisedorgeneralised.Skin lesionsusuallyoccuron the face (ear canal,perioral andperiocular skin, ventralneck)or in cutaneous folds (axillae,groin, interdigital skin and claw folds).

Malassezia dermatitis Malasseziapachydermatis and Staphylococcuspseudintermedius are alreadypresenton normaldog skin. Whenever the immune system is suppressed and/or the epidermalbarrier isdisrupted,microbial overgrowth can thenoccur.This can result inopportunistic skin and ear infections. 4

Clinical signs are variable andgenerallyobserved: • Erythema • Mild to severepruritus • Alopecia • Greasy exudation and scaling

Secondary lesions include: • Excoriations • Lichenification • Hyperpigmentation • Exudation

Ingeneralised cases, anoffensive and rancidodour is commonly reported. 6 Malassezia shouldbe considered in any casesofpruriticdermatitis.

Healthy epidermalbarrier

Disruptionof epidermalbarrier

As there is thought tobe an interactionbetween Malasseziapachydermatis and Staphylococcus pseudintermedius ,bothwill increase in numbers. 4

Neutrophilwith engulfed cocci

Bacterialovergrowth

Erythematous skin

Seborrhoeic skin